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RWD Life Science
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RWD Life Science
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RWD Life Science
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RWD Life Science
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RWD Life Science
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Image Search Results
Journal: CNS Neuroscience & Therapeutics
Article Title: Medial prefrontal cortical PPM1F alters depression‐related behaviors by modifying p300 activity via the AMPK signaling pathway
doi: 10.1111/cns.14293
Figure Lengend Snippet: C646 blocks the antidepressant activity of PPM1F overexpression in the mPFC. (A) Upper panel: Schematic diagram of the experimental timeline. Lower panel, histological verification, and hits map of the intra‐mPFC injection sites. (B) Female urine sniffing test. (C) Sucrose preference test. (D) Locomotor activity. AAV‐GFP + Vehicle group: n = 8, AAV‐PPM1F‐GFP + Vehicle group: n = 7; AAV‐PPM1F‐GFP + C646 group: n = 7. * p < 0.05, ** p < 0.01, compared to the control group.
Article Snippet: For intra‐mPFC microinjection of the
Techniques: Activity Assay, Over Expression, Injection, Control